Riboflavin - RFVT1 RFTV2 RFTV3

Mosegaard S, Dipace G, Bross P, Carlsen J, Gregersen N, Olsen RKJ. Riboflavin Deficiency—Implications for General Human Health and Inborn Errors of Metabolism. International Journal of Molecular Sciences. 2020; 21(11):3847

Evidence on effect of RF and its roles for reactive oxygen species in various symptoms and diseases.Upregulation↑, downregulation↓.

Suwannasom N, Kao I, Pruß A, Georgieva R, Bäumler H. Riboflavin: The Health Benefits of a Forgotten Natural Vitamin. Int J Mol Sci. 2020 Jan 31;21(3):950. doi: 10.3390/ijms21030950. PMID: 32023913; PMCID: PMC7037471

Be well: A potential role for
vitamin B in COVID-19

Shakoor, Hira et al. “Be well: A potential role for vitamin B in COVID-19.” Maturitas, S0378-5122(20)30348-0. 15 Aug. 2020, doi:10.1016/j.maturitas.2020.08.007

Conversion of Riboflavin to the
Active Coenzyme Forms

 (2008). Conversion of Riboflavin to the Active Coenzyme Forms

Riboflavin Deficiency—Implications for General Human Health and Inborn Errors of Metabolism

Riboflavin & Immune Response Henriques, Barbara & Olsen, Rikke & Bross, Peter & Gomes, Cláudio. (2010). Emerging Roles for Riboflavin in Functional Rescue of Mitochondrial ??-Oxidation Flavoenzymes. Current medicinal chemistry. 17. 3842-54. 10.2174/092986710793205462

Riboflavin Deficiency—Implications for General Human Health and Inborn Errors of Metabolism

Riboflavin & Immune Response Henriques, Barbara & Olsen, Rikke & Bross, Peter & Gomes, Cláudio. (2010). Emerging Roles for Riboflavin in Functional Rescue of Mitochondrial ??-Oxidation Flavoenzymes. Current medicinal chemistry. 17. 3842-54. 10.2174/092986710793205462

Theoretical BINDING TO SARS COV2 SPIKE PROTEIN Mpro Main Protease (B)

Theoretical BINDING RdRp (B)

Conversion oxidized glutathione (GSSG) to the reduced form (GSH) by glutathione reductase requires RF in the FAD co-enzyme form for its activity. G-6P-D, glucose-6-phosphate dehydrogenase [98]

Suwannasom N, Kao I, Pruß A, Georgieva R, Bäumler H. Riboflavin: The Health Benefits of a Forgotten Natural Vitamin. International Journal of Molecular Sciences. 2020; 21(3):950.

Complement and antibody receptors (CRs and FcRs) promote the uptake of micro-organisms by neutrophils, which, in turn, trigger the degranulation and production of ROS.

Suwannasom N, Kao I, Pruß A, Georgieva R, Bäumler H. Riboflavin: The Health Benefits of a Forgotten Natural Vitamin. International Journal of Molecular Sciences. 2020; 21(3):950.

RIBOFLAVIN in Functional rescue: Evidence-based theory for helping long haulers. 

Emerging Roles for Riboflavin in Functional Rescue of Mitochondrial β-Oxidation Flavoenzymes, 17(32): 3842 – 3854 Barbara J. Henriques, Rikke K. Olsen, Peter Bross and Claudio M. Gomes DOI: 10.2174/092986710793205462

Riboflavin Has Neuroprotective Potential: Focus on Parkinson’s Disease and Migraine

Marashly, E. T., & Bohlega, S. A. (2017). Riboflavin Has Neuroprotective Potential: Focus on Parkinson's Disease and Migraine. Frontiers in neurology, 8, 333. https://doi.org/10.3389/fneur.2017.00333

Riboflavin Can Effectively Inactivate Both Recombinant Adeno-Associated Viruses and Lentiviruses. A) Time Course of Inactivation for Recombinant Adeno-Associated Virus (AAV)

Callahan, S. M., Wonganan, P., Obenauer-Kutner, L. J., Sutjipto, S., Dekker, J. D., & Croyle, M. A. (2008). Controlled inactivation of recombinant viruses with vitamin B2. Journal of virological methods, 148(1-2), 132–145. https://doi.org/10.1016/j.jviromet.2007.10.027

CHIMERAX Model One

CHIMERAX Model Two

CHIMERAX Model Three

In-House Chimera - Early Riboflavin Intercalation Models

In-House Molecular Parametric Modeling to Test Our Geometric Underpinning Theories